How to get to Louisville in Project Zomboid, you ask? Well, that is something I can help you with. I have been playing PZ for some time now and have explored most of the entire map by now so you can trust me with providing directions.
It is quite easy actually, you just have to find a working car and some gas and you are all set. Of course you have to take enough supplies and everything you care about like generators, tools and basically everything you can carry for this can be your one final ride.
Now that you are all prepared, you just have to find the main highway that connects almost every urban areas in the game. I'm assuming you are familiar with Muldraugh so let's start from there.
The picture above is of the main highway in the game. Once you get there, just head north and at the end of it you will find the gated and walled off town you are looking for. If you are still now sure how, here is how to get to Louisville in Project Zomboid shown in a short video tutorial.